estrogen and progesterone
estrogen and progesterone balance. progesterone dominance. lever and sex hormones. higher progesterone levels present in perimenopausal women

In today’s aging society, in addition to the long-term life expectancy of people, the desire for a quality life has come to the fore.

The expected life expectancy of a woman born in the 20th century was only 48 years, and childhood illnesses accounted for a significant proportion of mortality.

Today it is stated that the average life expectancy of our women is 72 years. After the population projection of the VI.

Five-year development plan of the State Statistical Office is our female totalThe population in 2000 was 34,576,300 and our female population over 45 years old was 6,851,100.

According to this data, approximately 20% of our female population is in the postmenopausal period and will spend approximately 25 years of their life in menopause.

The goal of hormone replacement therapy is to reverse the effects on estrogen-responsive tissues and maintain the quality of life of postmenopausal women.

the effects of estrogen on the endometrium.

Currently, millions of postmenopausal women around the world are using estrogen as hormone therapy.

Hormone replacement therapy (HRT) was first introduced over 70 years ago. Its use has gradually increased over the past 20 years. , and women are more likely to choose HRT.

The main reason for the frequent use of HRT in the last 20-30 years is the increase in living standards and therefore life expectancy in developed countries.

The life expectancy of a woman turning 65 in the United States (US) today is 84.3 years.

The same applies to Sweden and Switzerland. In developed countries with an increasing proportion of older people, cardiovascular, locomotor, and cerebrovascular diseases and the prevention of these diseases are priorities.

The main factor behind HRT’s popularity is the belief that it prevents hip fractures in postmenopausal women and that HRT is a protective cardiovascular system in light of the literature accumulated over the years.

Research shows that hormone replacement therapy is effective in relieving menopausal symptoms such as hot flashes and vaginal dryness.

This treatment can also reduce the risk of osteoporosis. are known health risks and uncertainties associated with long-term use. Research

shows that hormone replacement therapy is effective in relieving menopausal symptoms such as hot flashes and vaginal dryness.

This treatment can also reduce the risk of osteoporosis. However, there are known health risks and uncertainties with long-term use.

Menopause Symptoms


Research shows that HRT is effective in relieving menopause symptoms such as hot flashes and vaginal dryness. This treatment can also reduce the risk of osteoporosis.

However, there are known health risks and uncertainties related to long-term use. Currently, women spend about 25 years of their lives in the post-menopausal period.

The symptoms of menopause that occur during this period significantly affect the quality of life of women.

Evidence: Studies based on hormone replacement therapy used to relieve menopausal symptoms have shown that estrogen therapy reduces vasomotor symptoms, improves urogenital symptoms and depression scores, and increases the quality of life.

In some of the studies using various estrogen supplements in relation to sleep disorders, estrogen was found to be effective while others found it to be ineffective.

This combination product, prepared as a sublingual (sublingual) drop, contains

Triple Estrogen 2.5 mg,

Progesterone 100 mg and

Testosterone 1 mg/ml and is suitable and effective for patients with special dosing requirements.


  • Estriol 20 mg
  • Estradiol 2.5 mg
  • Estrone 2.5 mg
  • Progesterone 1 g
  • Testosterone 10 mg
  • Micronized silica gel 200 mg
  • Saccharin 100 mg
  • Aroma (weak) qs
  • Almond oil 10 ml

Preparation of the formula: Calculate the required quantity of each ingredient for the total quantity to be prepared. Accurately weigh/measure each item. Mix estriol, estrone, estradiol, progesterone, testosterone, silica gel and saccharin in a mortar.Add a small amount of almond oil to the mixture.

Add aroma and mix well. Add a sufficient amount of almond oil and mix well. Usage: Used for natural hormone replacement therapy in postmenopausal women. resistant containers.Label: Use only as directed. Keep away from children.

Shelf life: This preparation should be used within a maximum of 6 months.

Sometimes patients may need specific dose adjustments for hormone replacement therapy. A combination product such as the formulation presented here can be made to conveniently deliver the required doses.

This formulation also allows for the administration of hormones that are not normally effective orally. These hormones are administered orally, topically, vaginally, and parenterally. Sublingual drops should be applied under the tongue.

It is important to choose a very mild flavor to minimize salivation and allow adequate time for absorption through the oral mucosa. These drops can be dosed using two different techniques.

First, a pipette can be calibrated by counting the number of drops made for a given volume, e.g. B. 1 ml, are required. Then divide by the amount needed to deliver the calculated doses in milliliters.

Alternatively, the patient may use an oral syringe or a standard 1 or 3 mL syringe (without a needle) to administer doses, particularly when the dose is 0.1 mL or more. In addition, the patient should be instructed to hold the drug under the tongue for a few minutes to allow absorption of the drug. Estriol is a natural estrogen.

It is said to have a selective effect on the cervix, vagina and vulva and a relatively minor effect on the endometrium. It is often given in combination with estrone and estradiol in estrogen replacement therapy.

It is a crystalline powder that is practically insoluble in water. , but soluble in alcohol and vegetable oils.

Estradiol is a naturally occurring steroid estrogen that occurs as small white to off-white crystals or crystalline powder. It is odorless and hygroscopic. Although practically insoluble in water, it has a solubility of about 35.7 mg/ml in alcohol at 25°C. C.

Should be stored in airtight, lightproof containers.In the body, estradiol is reversibly oxidized to estrone, and both estradiol and estrone can be converted to estrool. In general, estradiol is not administered orally due to extensive hepatic first-pass metabolism.

Estradiol is indicated for the treatment of atrophic vaginitis. , atrophic dystrophy of the vulva, menopausal symptoms, hypogonadism in women, ovarian surgery, primary ovarian failure, inoperable breast cancer, incurable prostate cancer, and mild to severe vasomotor symptoms associated with menopause.

Estrone is a naturally occurring steroidal estrogen made from the urine of pregnant mares or Mexican yam (Dioscorea).

It is a white to off-white crystalline powder in the form of small white crystals or odorless and practically insoluble in water.

It is soluble in vegetable oils and soluble in alcohol up to 4 mg/ml. ml suspension for injection.

Estrone is used in the treatment of hypogonadism, primary ovarian failure, vasomotor symptoms of menopause, prostate cancer, unresectable breast cancer, vulvar kraurosis, and abnormal uterine bleeding due to hormonal imbalance.

Progesterone is a naturally occurring progestin that occurs as a white or off-white crystalline powder that is practically insoluble in water, soluble in alcohol, and slightly soluble in vegetable oils. It melts at about 126-131°C and exists as a polymorph melting at 121°C.

Progesterone is extensively metabolized in the liver and is not generally administered orally, with few exceptions. It should be stored in airtight, lightproof containers.

Dust; It is odorless and stable in air.It is practically insoluble in water and 1 g is soluble in 5 ml ethanol, 2 ml chloroform and 100 ml ether.

It is soluble in vegetable oils. It melts between 153 and 157 °C. Testosterone undergoes photodegradation in the presence of light.

Testosterone is not highly bioavailable when administered as an oral preparation, but is absorbed and when administered oral sublingual.

Various testosterone esters are hydrolyzed to release testosterone and are then metabolized in the same way as testosterone itself.

Silica gel is a fine, white, hygroscopic, odorless, amorphous powder with a typical particle size of 2-10 µm. It is insoluble in water, alcohol, and other organic solvents, but soluble in hot solutions of alkali hydroxides.

It is used as a drying, suspending, and viscosity-increasing agent.

Saccharin (C7H5N03S, MW 183.18) is an intense sweetener commonly used in commercial products including foods, beverages, and pharmaceuticals. It is commonly used as a sweetener in the range of 0.02-0.5% in oral formulations.

It’s about 500 times sweeter than sucrose and can be used to mask off-flavors in medicines. It looks like odorless white crystals or white crystalline powder. It has a metallic aftertaste. 1 g is dissolved in 290 ml water, 50 ml glycerol and 31 ml 95% ethanol.

Almond oil (sweet almond oil, pressed almond oil, oleum amygdalae) is a clear, pale straw-colored or colorless, almost odorless oily liquid with a mild, nutty flavor.

It consists mainly of oleic glycerides with smaller amounts of linoleic, myristic, and palmitic acids.

Its specific gravity is 0.910-0.915 and it is easily soluble in alcohol.

Should be protected from light and stored in a cool place. It is commonly used as a plasticizer and solvent.

Sources: 1-Allen’s Composite Formulas: The Complete Collection of US Pharmacists / Loyd V. Allen, Jr.

,Editor-in-Chief.2-Evidence-Based Studies on Menopause and Hormone Replacement Therapy • Res.See.Emine SEN* • Asst.Assoc.

Read also: Progesterone as a Supplement: What To Know

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