Alopecia in Men Androgenetic Alopecia (AGA) is the most common cause of hair loss in men.
alopecia androgenetic AGA, also known as common hair loss, male pattern baldness, and male pattern baldness, is a form of hair loss caused by the action of androgens in people with a genetic predisposition.
The disease has been found to be caused by androgens in genetically predisposed individuals. Recent publications have found that even normal levels of androgen are sufficient for hair loss in genetic individualsPredisposition.
Two agents approved by the US Food and Drug Administration (FDA) for the treatment of AGA alopecia androgenetic in men; are topical minoxidil and oral finasteride.
In order to avoid the side effects that can occur when taking finasteride orally, formulations with local applications are used today.
For example, the following preparation is used in the treatment of male androgenetic alopecia. Formula: Minoxidilfor 100 ml 10 g finasteride 100 mg biotin 200 mg caffeine citrate 50 mg propylene glycol 10 g distilled water 30 ml 20% sulfuric acid solution pH 4.5-5.0 96% ethyl alcohol qs 100 ml substances in the formula;>
Minoxidil
(Loniten, Rogaine, C9H15N5O, MW 209.25) is used as a topical antihypertensive and hair growth stimulant.
Minoxidil is a white to the off-white crystalline structure, odorless, readily soluble in water up to about 2 mg/mL.
Easily soluble in propylene glycol or ethanol; and insoluble in acetone or ethyl acetate. Minoxidil is commercially available as a 2-5% topical solution and as a foam in a variety of forms.
Finasteride (Propecia, Proscar, C23H36N2O2, MW 372.54) is slightly soluble in water and very soluble in alcohol, with a melting point of approximately 257°C. It is white, whitish, and crystalline.
It is only used to treat male pattern baldness (androgenetic alopecia) in men.
It is a 5-alpha reductase inhibitor and is mainly used to treat an enlarged prostate or male pattern hair loss.
This medication is not intended for use in women and children.
Biotin
(Bioepiderm, Coenzyme R, Vitamin B7, Vitamin H, Factor W, C10H16N2O3S, MW 244.31) is a white crystalline powder, slightly soluble in water and alcohol.
Vitamin Biotin is also commonly used to treat hair loss, brittle nails, and other ailments.
Caffeine citrate
(Cafcit, C14H18N4O9, MW 386.31) is known as a white, odorless powder with a slightly bitter acid taste. 1 g dissolves in approx. 4 ml of warm water.
Propylene Glycol
(C3H8O2) is a clear, colorless, viscous, practically odorless, sweet liquid with a taste similar to glycerin.
It has a specific gravity of 1.038 g/ml and is miscible with acetone, chloroform, 95% ethanol, glycerin, and water.
Ethyl alcohol
(alcohol, ethanol, grain alcohol, C2H5OH, PM 46.07) is a clear, colorless, volatile liquid with a mild, characteristic odor and a burnt taste. Miscible with chloroform, glycerin, and water.
Preparing the formula:
To prepare the total amount, the required amount of each ingredient is accurately calculated and weighed or measured.
Propylene glycol, ethyl alcohol (40 mL), and distilled water are mixed together.
Minoxidil is dissolved by adding it to this mixture.
Add slowly and dropwise to the solution until the 20% sulfuric acid solution reaches a pH between 4.5 and 5.
Biotin, finasteride, and caffeine citrate are added and mixed well.
The formula is made by adding a sufficient amount of ethyl alcohol and mixing well until the final volume is reached.
It should be packed in well-sealed, light-resistant containers.
Labeling: Keep out of the reach of children.
For external use only.Stability: This formula can be used for up to 30 days after opening the container.
Read also: Androgenetic Alopecia Treatment Options
